KMID : 0895420010110020135
|
|
Journal of Korean Society of Occupational and Enviromental Hygiene 2001 Volume.11 No. 2 p.135 ~ p.144
|
|
Urinary Metabolites of Dimethylformamide, Methyl Ethyl Ketone, and Toluene exposed Workers in Synthetic Leather Factories
|
|
ÃÖÈ£Ãá/Choi, Ho-Chun
±è°À±/¾È¼±Èñ/ÀÌ¿µÀÚ/Á¤±Ôö/Kim, Kang Yoon/An, Sun-Hee/Lee, Young-Ja/Chung, Kyou-Chull
|
|
Abstract
|
|
|
This study was performed to measure airborne dimethyl-formamide(DMF), methyl ethyl ketone(MEK) and toluene and their urinary metabolites concentrations and to determine the relationship between airborne and urinary concentration. Air-borne samples and their urinary metabolites were measured 98male workers who work for 8 synthetic leather factories in a portion of Kyoung-in area. Urine samples were collected at end-of-shift to estimate the exposure levels.
1. The concentration of airborne DMF by process was 8.81 ppm for wet-mixing, 15.05 ppm for wet-coating, 6.03 ppm for dry-mixing, 5.58 ppm for dry-coating, 5.37 ppm for printing, and 9.03 ppm for total. There was statistically significant difference by process. Urinary NMF concentrations of wet-mixing, Wet-coasting, Dry-mixing, dry-coating and printing were 90.55§·/, 79.80§·/§¤, 39.86§·/§¤, 25.23§·/§¤, and 38.15§·/§¤, respec-tively, and total geometric mean was 56.24§·/§¤. There was statistically significant difference by process.
2. The concentration of airborne MEK by process was 1.89 ppm for wet-mixing, 1.96 ppm for wet-coating, 10.33 ppm for dry-mixing, 29.24 ppm for dry-coating, 14.98 ppm for printing, and 4.87 ppm for total. There was statistically significant difference by process. Urinary MEK concentrations of wet-mxing, wet-coating, dry-mixing, dry-coating and printing were 0.93§·/§¤, 0.70§·/§¤, 3.29§·/§¤, 3.29§·/§¤, and 1.06§·/§¤, res-pectively, and total geometric mean was 1.25§·/§¤, There was statistically significant difference by process. Urinary MEK
3.The concentration of airborne toluene by process was 0.35ppm for wet-mixing, 0.42ppm for wet-coating, 2.95ppm for dry-mixing, 11.67ppm for dry-coating, 4.88ppm for printing, 1.24ppm for total. There was statistically significant difference by process. Urinary hippuric acid concentrations of wet-mixing, wet-coating, dry-mixing, dry-coating and printing were 0.24g/g creatinine, 0.21g/g creatinine, 0.34g/g creatinine, 0.52g/g cre-atinine, and 0.29g/g creatinine, respctively and total geometric mean was 0.28g/g creatinine. There was statistically signifi-cant difference by process.
4. No. of exceeded KPEL was 40 workers(40.8%) for DMF(10ppm), 1 worker(1.0£¥) for MEK(200ppm), and no worker for toluene(100ppm). No. of exceeded KBEI was 62 workers(63.3£¥) for urinary NMF(40§·/§¤), 29 workers (29.6£¥) for uri-nary MEK, 1 worker(1.0£¥) for urinary hippuric acid.
5. The regression equations were Log(MMF)=0.4094* Log(DMF)+1.3587(r=0.4516) for DMF, Log(MEKU)=0.1859* Log(MEK)-0.0324(r=0.3303) for MEK, Log(HA)=0.2106* Log(Toluene)-0.5685 (r=4497) for toluene.
Synthetic leather factory workers expose to 3 kinds of organic solvents which are DMF, MEK and toluene. Their Uri-nary NMF and MEK levels were higher than their concentration levels through respiratory. It seems that the urinary levels were affected skin absorption for working habit and alcohol intake.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|